Recombinant blood group proteins

Detection and identification of clinically significant blood group specific antibodies in patients requiring blood transfusion can be difficult if antibodies to high frequency antigens are also present.

This can include therapeutic monoclonal antibodies, some of which target molecules expressed on the red cell membrane (e.g. Daratumumab, which recognises CD38).

Soluble recombinant (sr) proteins can be used to inhibit haemagglutination by these ‘nuisance’ antibodies, allowing identification of underlying clinically significant antibodies.

Sr proteins are pre-incubated with patient serum or plasma before addition of the inhibited patient sample to panel red blood cells.

These products are available to UK transfusion services and overseas customers.

A quote for delivery will be provided on request (carriage free within the UK).

Product information

Knops Inhibition Reagent (KNIR)

Product code: 9497

KNIR contains a mixture of two srCR1 proteins that inhibit red cell agglutination by CR1-related antibodies in both gel and tube agglutination tests.

One vial of KNIR is sufficient for up to 12 inhibition reactions.

Product now shipped at ambient temperature - transfer to -20°C on receipt and store frozen.

Download KNIR datasheet (PDF 82KB)

Soluble recombinant CD38 (srCD38)

Product code: 9506

Inhibits red cell agglutination by therapeutic anti-CD38 monoclonal antibodies (e.g. Daratumumab), in both gel and tube agglutination tests.

One vial of srCD38 is sufficient for up to 6 inhibition reactions.

Product now shipped at ambient temperature - transfer to -20°C on receipt and store frozen.

Download srCD38 datasheet (PDF 96KB)

Prices

All of our products are exclusive of VAT.  We ship our purified recombinant blood group protein products worldwide by courier (Flight Logistics Group) and shipping fees will apply. Contact us if you require a quote, or have alternative courier arrangements. 

Price List valid until March 2022.

Quantity
(vials)
KNIR
GBP/vial
srCD38
GBP/vial
1+ 50.00 120.00
5+ 45.00 110.00
10+ 40.00 100.00

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