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IBGRL was set up in 1946 to centralise production of blood grouping
reagents and provide a reference centre for the newly formed National
Blood Transfusion Service. Until 1984, all blood grouping reagents were
prepared by selecting, absorbing and pooling human sera of blood donors.
In 1982 a monoclonal antibody development laboratory was set up at IBGRL.
The laboratory also financed the development of human monoclonal anti-D at
Babraham, Cambridge and UKTS, Bristol. At this time the Immunochemistry
Section of the SW Regional Transfusion Centre (SWRTC) was exploring the
development of monoclonal antibodies to blood group active structures on
red cells. The Immunochemistry department joined IBGRL and the SWRTC was
renamed the National Blood Service (NBS) Midlands and South West
Zone, Bristol Centre.
IBGRL Research Products Leaflet
IBGRL FMH Leaflet - short
IBGRL FMH Leaflet - long
Who We Are
Since April 1991, the International Blood Group Reference Laboratory (IBGRL) has had a range of monoclonal antibodies for immunohaematological research marketed under the name "IBGRL Research Products". The antibodies cover a range of specificities of interest to researchers in the fields of immunology, haematology, cell biology and biochemistry. The introduction of these products marked a divergence from the laboratory's original role of supplying reagents solely for blood group serology.
Over the years, the monoclonal antibodies have been developed and grown at IBGRL by the Protein Development and Production Unit (PDPU) and production team. These are the current members of the PDPU.
From left to right: Linda Motz, Rosey Mushens, Alan Guest, Terri Stutt and Jonathan Dixey.
Rosey (BSc, PhD) is the PDPU manager and has over 25 years of experience in producing/developing monoclonal antibodies. Alan (BSc) is the longest serving member of the team and specializes in the purification and conjugation of antibodies. Jonathan (BSc) joined us in April 2000 and is deputy to Rosey, specialising in cell culture and antibody production. Linda (BSc/MSc) joined us in 2013 and produces antibody reagents as well as assisting stem cell with specialised cell banks. Terri (BSc/BMS) joined us in 2014 and is vital in that she keeps the team working efficiently. She ensures we have whatever we need for our jobs to run smoothly.