IBGRL Red Cell Reference

      

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Red Cell Reference

The International Rare Donor Panel 

Molecular Diagnostics User Guides Sending Samples Red Cell Reference

Red cell serology services are provided ONLY to UK Blood Centres and to bona fide reference centres outside the UK. 
Centres wishing to refer for the first time must contact IBGRL to discuss the appropriateness of the proposed investigation.

Other types of referrals can be considered but please telephone to discuss the case before sending samples.

Contact Details   Address Details

Nicole Thornton (Head of Red Cell Reference)
 Tel: +44 (0)117 921 7586 
Email: nicole.thornton@nhsbt.nhs.uk

Shane Grimsley (Reference Serology Deputy Manager)
Tel: +44 (0) 117  921 7587
Email: shane.grimsley@nhsbt.nhs.uk

FAX (lab) +44 (0) 117 921 7329
FAX (admin office): +44 (0) 117 912 5796

IBGRL Red Cell Reference lab,
NHSBT Filton Blood Centre
North Bristol Park,
Filton
Bristol
BS34 7QH

UK

 

Working Hours
Our normal working hours are:
Monday - Thursday 9.00am - 5.30pm, Friday 9.00am - 5.00pm

Urgent cases can be investigated outside of these hours but it is essential to liaise with the Red Cell Reference Laboratory prior to sending the samples.

 

Type of Investigation Samples Required Notes
Investigation of antibody to a high-incidence antigen or a mixture of antibodies . Patient (or donor) whose serum/plasma contains antibody(ies) to all or the majority of red cells (i.e. antibody to a high incidence antigen or a complex mixture of antibodies)  

10ml clotted blood
PLUS
10ml anticoagulated blood 

 
Includes confirmation of rarity previously determined by the referrer and determination of possible underlying specificities. 

Larger samples are preferable and sometimes may be essential. Anticoagulated
samples should not be separated. Separation of clotted samples is optional.
Investigation of antibody to a low-incidence antigen. Patient (or donor) whose serum/plasma contains antibody to a single example of donor cells or the baby’s/fathers cells in case of maternal antibody (i.e. antibody to a low incidence antigen).   

Minimum of 10ml clotted blood from the patient
PLUS 
10ml anticoagulated blood from the incompatible donor/father (less from a baby). 

  This type of investigation cannot be carried out unless the incompatible cells are received. The incompatibility should have a minimum 3+ reaction ( on a scale of 1+ to 5+).
Difficult or discrepant typing (any phenotype)  

Minimum of 10ml anticoagulated sample. 

 
ABO problems and partial D problems with anti-D cannot be investigated without either plasma or serum for antibody confirmation
.

 

Referring UK Laboratories

Referring International Laboratories

Non urgent samples should be sent by first class mail. Urgent samples should be sent by courier ensuring door-to-door delivery, preferably to arrive during lab working hours.

Urgent referrals are defined as those where blood for transfusion is needed as quickly as possible. It is essential that the Red Cell Reference laboratory is contacted by telephone prior to sending samples of this nature.

Please note:

Samples are accepted from NHSBT, SNBTS and Welsh BTS reference laboratories and overseas reference laboratories ONLY.

Please note:
NHSBT ‘round robin’ is not a reliable way of sending samples for investigation.
Samples from UK hospitals will only be investigated with the knowledge of their local blood centre.

  Samples should be sent by ‘express’ mail, courier or by air freight ensuring door-to-door delivery, preferably to arrive during lab working hours.

Urgent referrals are defined as those where blood for transfusion is needed as quickly as possible. It is essential that the Red Cell Reference laboratory is contacted by telephone prior to sending samples of this nature.

Please note that Samples are accepted from NHSBT, SNBTS and Welsh BTS reference laboratories and overseas reference laboratories ONLY.

 

 

Paperwork accompanying samples

There is no IBGRL Form to use for referring Red Cell Reference samples. Please use a form from your own institution, or include the following details on headed paper:

Full address for correspondence

Clinical background and investigation required

List of samples included in the package

Indication of urgency of investigation.

Declaration of infection risk status if known.

Please ensure that the labelling on all samples corresponds to the identification in the accompanying letter, with at least three forms of identification 
(e.g. Name, date of birth, hospital number). 

Please indicate if the report should be sent to an individual other than the referrer.

 

Reporting Results

Reports will normally be sent by first class mail. When requested, results will be given over the telephone and will be confirmed by Email or Fax. Urgent cases may be reported by Email or Fax. Samples submitted through the NHSBT Laboratory Information Management System (Hematos) will be reported through Hematos. 

The time between receipt of sample and reporting will depend on the urgency of the case and the number of samples in the laboratory at any given time (which is out of our control). Priority is always given to urgent cases and therefore non-urgent investigations may be necessarily delayed. The referrer will be informed if there is to be undue delay in starting an investigation for this reason.